Is Reishi (Ganoderma lucidum) Safe with Cyclosporine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid Reishi supplementation while on cyclosporine. Inform your transplant or rheumatology team if you are currently taking this combination.
Why this interaction occurs
Reishi's immunostimulating beta-glucans and polysaccharides may antagonize cyclosporine's T-cell suppression. Additionally, Reishi may inhibit CYP3A4 enzyme activity, potentially raising cyclosporine blood levels and increasing nephrotoxicity risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,058 reports mentioning Cyclosporine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Cyclosporine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Reishi (Ganoderma lucidum) interactions → · All Cyclosporine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.