Is Calcium Safe with Cyclosporine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use calcium supplements cautiously and only under physician guidance. Monitor kidney function and serum calcium levels regularly, as cyclosporine-induced nephrotoxicity can impair calcium regulation.
Why this interaction occurs
Cyclosporine causes renal vasoconstriction and nephrotoxicity, which can impair calcium and phosphate homeostasis regulated by the kidneys. Hypercalcemia has been reported in patients on cyclosporine, possibly due to altered vitamin D metabolism and parathyroid hormone dynamics. Calcium supplementation requires careful monitoring in this context.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,058 reports mentioning Cyclosporine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Cyclosporine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium interactions → · All Cyclosporine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.