Is Magnesium Safe with Cyclosporine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take magnesium supplements at least 2 hours apart from cyclosporine. Inform your transplant team before starting any magnesium supplement. Monitor magnesium and cyclosporine trough levels regularly.
Why this interaction occurs
Cyclosporine causes renal magnesium wasting (hypomagnesemia) in up to 50% of transplant patients by inhibiting tubular reabsorption. While magnesium supplementation is often necessary, high-dose magnesium can potentially alter cyclosporine absorption and complicate nephrotoxicity monitoring. Careful timing and dose management are essential.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,058 reports mentioning Cyclosporine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Cyclosporine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Cyclosporine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.