Is GLA Evening Primrose Oil Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid concurrent use without prescriber approval. Report any unusual bruising or bleeding immediately. INR should be monitored more frequently.
Why this interaction occurs
GLA-derived prostaglandins (PGE1) inhibit platelet aggregation and may enhance warfarin's anticoagulant activity, raising the risk of serious bleeding events.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All GLA Evening Primrose Oil interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.