Is Iron Safe with Bictegravir?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take iron supplements at the same time as Bictegravir (co-formulated as Biktarvy). Separate iron by at least 2 hours before or 2 hours after Bictegravir when taken with food. Follow prescribing information guidance carefully as this is a labeled interaction.
Why this interaction occurs
Like Dolutegravir, Bictegravir contains a metal chelation motif essential for integrase inhibition. Iron cations bind this motif and reduce Bictegravir plasma exposure significantly. This interaction is included in the FDA-approved prescribing information for Biktarvy.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 2,633 reports mentioning Bictegravir. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Bictegravir + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Iron interactions → · All Bictegravir interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.