Is Lemon Balm Safe with Clonazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not use Lemon Balm while taking Clonazepam without medical supervision. Report unusual drowsiness, confusion, or difficulty breathing to your healthcare provider immediately.
Why this interaction occurs
Clonazepam is a benzodiazepine that enhances GABA-A receptor activity. Lemon Balm's GABAergic mechanism compounds this effect, risking excessive sedation, respiratory depression, and psychomotor impairment. The combination may also prolong the sedative half-life effect clinically.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 122,823 reports mentioning Clonazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Clonazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Lemon Balm interactions → · All Clonazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.