Is Magnesium Safe with Risedronate?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate risedronate and magnesium supplementation by at least 2 hours. Preferably take risedronate upon waking and schedule magnesium with lunch or dinner.
Why this interaction occurs
Magnesium forms stable chelate complexes with risedronate's bisphosphonate structure, reducing GI absorption. This interaction is documented in risedronate's prescribing information and mirrors the well-characterized interaction seen with calcium.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 17,651 reports mentioning Risedronate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Risedronate + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Risedronate interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.