Is Resveratrol Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid concurrent use or monitor INR closely every 1-2 weeks if combination is deemed necessary. Report any unusual bruising, bleeding gums, or prolonged bleeding to your healthcare provider immediately.
Why this interaction occurs
Resveratrol inhibits CYP2C9, the primary enzyme responsible for warfarin metabolism, leading to elevated warfarin plasma levels and significantly increased anticoagulant effect. Additionally, resveratrol has intrinsic platelet aggregation inhibitory properties, compounding hemorrhagic risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Resveratrol interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.