Is Resveratrol Safe with Apixaban?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use with caution. Inform your prescribing physician before starting resveratrol. Watch for signs of bleeding including blood in urine or stool, unusual bruising, or excessive menstrual bleeding.
Why this interaction occurs
Resveratrol inhibits P-glycoprotein (P-gp) and CYP3A4, both involved in apixaban transport and metabolism. This inhibition may increase apixaban bioavailability and reduce clearance. Combined antiplatelet activity of resveratrol further amplifies bleeding risk in patients on direct oral anticoagulants.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 67,478 reports mentioning Apixaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Apixaban + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Resveratrol interactions → · All Apixaban interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.