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Is St. John's Wort Safe with amiodarone?

⚠️ HIGH SEVERITY
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amiodarone St. John's Wort
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid taking St. John's Wort while on amiodarone. Due to amiodarone's long half-life, this interaction may persist for weeks to months after stopping either product.

Why this interaction occurs

St. John's Wort is a CYP450 inducer that reduces amiodarone serum levels, potentially decreasing its antiarrhythmic effectiveness.

Evidence

Evidence level: strong.

Data source

FDA Drug Label

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 65,378 reports mentioning amiodarone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the amiodarone + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take St. John's Wort with amiodarone?
Avoid unless your doctor or pharmacist directs otherwise. Avoid taking St. John's Wort while on amiodarone. Due to amiodarone's long half-life, this interaction may persist for weeks to months after stopping either product.
How long should I wait between amiodarone and St. John's Wort?
Avoid taking St. John's Wort while on amiodarone. Due to amiodarone's long half-life, this interaction may persist for weeks to months after stopping either product.
Does St. John's Wort affect how well amiodarone works?
St. John's Wort is a CYP450 inducer that reduces amiodarone serum levels, potentially decreasing its antiarrhythmic effectiveness.

Related interactions

Grapefruit Juice and amiodarone St. John's Wort and cyclosporine St. John's Wort and warfarin St. John's Wort and indinavir St. John's Wort and oral contraceptives St. John's Wort and Tricyclic Antidepressants (Amitriptyline, Nortriptyline, Doxepin, Imipramine, Desipramine, Amoxapine) St. John's Wort and Direct-Acting Oral Anticoagulants (DOACs) — excluding Dabigatran St. John's Wort and Serotonergic Antidepressants (SSRIs, SNRIs)

All St. John's Wort interactions →  ·  All amiodarone interactions →

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