Is St. John's Wort Safe with escitalopram?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid taking St. John's Wort while using escitalopram. If serotonin syndrome symptoms occur (such as agitation, confusion, rapid heart rate, or muscle twitching), discontinue use and contact your healthcare provider immediately.
Why this interaction occurs
Concomitant use of escitalopram and St. John's Wort increases the risk of serotonin syndrome due to additive serotonergic effects.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 77,785 reports mentioning escitalopram. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the escitalopram + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All St. John's Wort interactions → · All escitalopram interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.