Is St. John's Wort Safe with trazodone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take St. John's Wort while using trazodone. Seek immediate medical attention if you experience agitation, confusion, rapid heart rate, sweating, muscle twitching, or high fever.
Why this interaction occurs
Concomitant use of serotonergic drugs including trazodone and other serotonergic agents such as St. John's Wort increases the risk of serotonin syndrome. Monitor patients for signs and symptoms of serotonin syndrome, particularly during trazodone initiation. If serotonin syndrome occurs, consider discontinuation of trazodone and/or concomitant serotonergic drugs.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 122,875 reports mentioning trazodone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the trazodone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All St. John's Wort interactions → · All trazodone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.