Is St. John's Wort Safe with vilazodone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid taking St. John's Wort with vilazodone. If serotonin syndrome occurs (symptoms may include agitation, hallucinations, rapid heart rate, fever, muscle twitching, or nausea), seek medical attention immediately and contact your doctor about discontinuing one or both substances.
Why this interaction occurs
Concomitant use of vilazodone with other serotonergic drugs, including St. John's Wort, increases the risk of serotonin syndrome, particularly during vilazodone initiation.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 1,826 reports mentioning vilazodone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the vilazodone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All St. John's Wort interactions → · All vilazodone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.