Is Vitamin D Safe with Tacrolimus?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Have your vitamin D levels checked regularly. Tacrolimus-induced nephrotoxicity can impair renal activation of vitamin D. Supplement as directed by your physician; do not self-prescribe high doses of active vitamin D analogs (calcitriol) without medical oversight.
Why this interaction occurs
Tacrolimus causes nephrotoxicity that can impair the kidney's ability to convert 25-hydroxyvitamin D to its active form (1,25-dihydroxyvitamin D3/calcitriol). This leads to functional vitamin D deficiency, impaired calcium absorption, and increased risk of post-transplant bone disease. Supplementation with standard vitamin D3 is generally recommended.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 130,929 reports mentioning Tacrolimus. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tacrolimus + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Tacrolimus interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.