Is Calcium Safe with Tacrolimus?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Space calcium supplementation at least 2 hours apart from tacrolimus doses. Monitor tacrolimus blood levels regularly, especially when starting or stopping calcium supplements.
Why this interaction occurs
High-dose calcium supplements may theoretically alter gastrointestinal pH and motility, potentially affecting tacrolimus absorption. Additionally, tacrolimus itself can cause hypomagnesemia and contribute to electrolyte imbalances that interact with calcium homeostasis, warranting careful monitoring.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 130,929 reports mentioning Tacrolimus. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tacrolimus + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium interactions → · All Tacrolimus interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.