Is Reishi (Ganoderma lucidum) Safe with Tacrolimus?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not use Reishi mushroom supplements if you are taking tacrolimus. Consult your transplant specialist immediately before making any changes.
Why this interaction occurs
Reishi exhibits immunomodulatory and immunostimulating properties that may counteract the immunosuppressive effects of tacrolimus, potentially triggering organ rejection in transplant patients. Reishi polysaccharides and triterpenes activate NK cells and macrophages, directly opposing tacrolimus mechanism.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 130,929 reports mentioning Tacrolimus. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tacrolimus + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Reishi (Ganoderma lucidum) interactions → · All Tacrolimus interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.