Is Bromelain Safe with Ibuprofen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution when combining bromelain with ibuprofen. Monitor for increased GI side effects such as stomach upset or bleeding. Consider spacing doses and taking ibuprofen with food.
Why this interaction occurs
Bromelain may enhance intestinal permeability and increase the absorption of ibuprofen, potentially elevating plasma concentrations and intensifying both therapeutic and adverse GI effects of the NSAID.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 218,701 reports mentioning Ibuprofen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ibuprofen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Bromelain interactions → · All Ibuprofen interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.