Is Devils Claw Safe with Ibuprofen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution when combining Devil's Claw with Ibuprofen or other NSAIDs. Take with food, monitor for stomach pain, nausea, or signs of GI bleeding such as dark stools. Discuss with your doctor if long-term use is planned.
Why this interaction occurs
Devil's Claw has demonstrated anti-inflammatory activity via inhibition of COX and LOX pathways. Combined with NSAIDs like Ibuprofen, this creates additive anti-inflammatory and potential additive gastrointestinal mucosal irritation effects.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 218,701 reports mentioning Ibuprofen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ibuprofen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Devils Claw interactions → · All Ibuprofen interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.