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Is Milk Thistle Safe with Ibuprofen?

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Ibuprofen Milk Thistle
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Use caution combining Milk Thistle with Ibuprofen. Milk Thistle may mildly slow Ibuprofen metabolism via CYP2C9. Monitor for increased side effects.

Why this interaction occurs

Silymarin inhibits CYP2C9 in vitro — clinical significance unclear. Result: slightly increased drug levels.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 218,701 reports mentioning Ibuprofen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ibuprofen + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Milk Thistle with Ibuprofen?
Generally yes, with awareness that Use caution combining Milk Thistle with Ibuprofen. Milk Thistle may mildly slow Ibuprofen metabolism via CYP2C9. Monitor for increased side effects.

Related interactions

Fish Oil and Ibuprofen Willow Bark and Ibuprofen Turmeric and Ibuprofen Bromelain and Ibuprofen Devils Claw and Ibuprofen St. John's Wort and Ibuprofen Curcumin and Ibuprofen Ginkgo Biloba and Ibuprofen

All Milk Thistle interactions →  ·  All Ibuprofen interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.