Is Bromelain Safe with Aspirin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining bromelain supplements with antiplatelet agents like aspirin unless directed by a physician. Discontinue bromelain at least 2 weeks before any surgical procedure.
Why this interaction occurs
Bromelain, a proteolytic enzyme from pineapple, has demonstrated independent antiplatelet and fibrinolytic properties. When combined with aspirin, it may produce additive inhibition of platelet aggregation, increasing hemorrhagic risk.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 617,935 reports mentioning Aspirin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Aspirin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Bromelain interactions → · All Aspirin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.