Is Fisetin Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining fisetin with warfarin unless under close medical supervision with frequent INR monitoring. Fisetin supplements should be discontinued at least 2 weeks before elective procedures.
Why this interaction occurs
Fisetin, a flavonoid senolytic, demonstrates significant CYP2C9 inhibitory activity in vitro and in preclinical studies. As warfarin is primarily metabolized by CYP2C9, co-administration may substantially increase warfarin exposure. Fisetin also inhibits platelet aggregation and has antithrombotic properties, creating additive hemorrhagic risk.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Fisetin interactions → · All Warfarin interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.