Is Folic Acid Safe with Enalapril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Patients with H-type hypertension (homocysteine ≥10 µmol/L) taking enalapril may benefit from concurrent folic acid supplementation (0.8 mg/day); maintain high adherence (≥70%) to achieve significant cardiovascular risk reduction.
Why this interaction occurs
Combined enalapril-folic acid therapy in patients with hemorrhagic stroke and H-type hypertension showed significantly reduced CVD risk (HR 0.16), recurrent stroke (HR 0.21), and all-cause mortality (HR 0.14) with high adherence compared to low adherence, suggesting a synergistic cardiovascular protective effect.
Evidence
Evidence level: moderate.
Data source
PubMed - PMID 42410840
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 61,312 reports mentioning Enalapril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Enalapril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Folic Acid interactions → · All Enalapril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.