Is Vitamin D Safe with Enalapril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Vitamin D supplementation (1000–2000 IU/day) is generally safe with Enalapril and may be beneficial for cardiovascular health. Ensure total daily vitamin D intake does not exceed 4000 IU without physician guidance. Monitor calcium levels if high-dose vitamin D is used.
Why this interaction occurs
Vitamin D deficiency has been associated with upregulation of the renin-angiotensin-aldosterone system (RAAS). Supplementing vitamin D in deficient patients may enhance the blood pressure-lowering effect of Enalapril and provide additional cardioprotective benefits, though excessive vitamin D can raise calcium levels and indirectly affect blood pressure.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 61,312 reports mentioning Enalapril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Enalapril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Enalapril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.