Is Magnesium Safe with Invokana?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Have serum magnesium checked before starting supplementation. Do not self-initiate high-dose magnesium without medical supervision due to risk of imbalance.
Why this interaction occurs
Invokana (canagliflozin) promotes glucosuria and osmotic diuresis, which increases renal magnesium wasting. This can lead to hypomagnesemia, particularly in patients with poor dietary intake. Supplementation may be warranted but should be medically guided.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 26,882 reports mentioning Invokana. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Invokana + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Invokana interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.