Is Magnesium Safe with Naproxen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take naproxen and magnesium supplements at least 2 hours apart to minimize interference with absorption. Long-term NSAID users should periodically monitor magnesium levels with their physician.
Why this interaction occurs
Chronic NSAID use, including naproxen, can promote renal magnesium wasting through prostaglandin-mediated effects on tubular reabsorption. Additionally, GI changes from NSAID use may reduce magnesium absorption. Prolonged combined use may contribute to subclinical hypomagnesemia, affecting muscle and nerve function.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 96,214 reports mentioning Naproxen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Naproxen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Naproxen interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.