Is Devils Claw Safe with Naproxen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid routine combination of Devil's Claw with Naproxen unless directed by your doctor. If used together, take with food and a stomach-protecting agent if recommended. Report any stomach pain, dark stools, or vomiting of blood immediately.
Why this interaction occurs
Devil's Claw inhibits prostaglandin synthesis through COX pathway modulation, similar in mechanism to NSAIDs like Naproxen. Concurrent use may amplify both therapeutic anti-inflammatory effects and adverse gastrointestinal effects including ulceration and bleeding.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 96,214 reports mentioning Naproxen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Naproxen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Devils Claw interactions → · All Naproxen interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.