Is Milk Thistle Safe with Naproxen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
No specific action required at typical doses.
Why this interaction occurs
Silymarin is a weak CYP2C9 inhibitor in vitro; not clinically significant at therapeutic supplement doses.
Evidence
Evidence level: moderate.
Data source
NCCIH milk thistle; CYP2C9 inhibition literature
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 96,214 reports mentioning Naproxen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Naproxen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Milk Thistle interactions → · All Naproxen interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.