Is Turmeric Safe with Naproxen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Limit turmeric supplement use while on naproxen. If GI symptoms such as stomach pain, nausea, or dark stools occur, discontinue turmeric and contact your healthcare provider.
Why this interaction occurs
Both naproxen (COX-1/COX-2 inhibition) and curcumin reduce prostaglandin synthesis and impair platelet function. The combination increases risk of GI mucosal damage, peptic ulceration, and bleeding events.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 96,214 reports mentioning Naproxen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Naproxen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Turmeric interactions → · All Naproxen interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.