Is Melatonin Safe with Mirtazapine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use with caution. Avoid driving or operating heavy machinery. Discuss melatonin use with your doctor, especially if you are experiencing excessive daytime sleepiness. Start with the lowest effective melatonin dose if approved.
Why this interaction occurs
Mirtazapine has potent antihistaminergic and sedating properties, particularly at lower doses. Melatonin promotes sleep onset through MT1/MT2 receptor agonism. Their combined use may produce additive CNS depression and excessive sedation, impairing daytime functioning and psychomotor performance.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 77,936 reports mentioning Mirtazapine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Mirtazapine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Melatonin interactions → · All Mirtazapine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.