Is Reishi (Ganoderma lucidum) Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Reishi with warfarin. If already taking both, monitor INR closely and report unusual bruising or bleeding to your provider immediately.
Why this interaction occurs
Reishi has demonstrated antiplatelet and anticoagulant properties in clinical studies. Its triterpenes inhibit platelet aggregation, and it may potentiate warfarin's anticoagulant effect, leading to elevated INR and serious bleeding risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Reishi (Ganoderma lucidum) interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.