Is Resveratrol Safe with Bortezomib (Velcade)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not use resveratrol supplements during bortezomib chemotherapy cycles. Discontinue at least 2 weeks before starting bortezomib. Discuss any antioxidant supplement use with your oncologist.
Why this interaction occurs
Resveratrol activates NF-κB cytoprotective pathways and induces antioxidant responses that directly antagonize bortezomib's mechanism of proteasome inhibition and pro-apoptotic activity in malignant cells. Animal and cell-line studies demonstrate significantly reduced bortezomib efficacy.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 90,368 reports mentioning Bortezomib (Velcade). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Bortezomib (Velcade) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Resveratrol interactions → · All Bortezomib (Velcade) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.