Is Rhodiola Safe with Lisinopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Check blood pressure at home regularly if using Rhodiola with ACE inhibitors. Be cautious with activities requiring alertness if you feel lightheaded. Discuss Rhodiola use with your prescriber before starting, especially if your blood pressure is already at target or below.
Why this interaction occurs
Rhodiola rosea may exert mild vasodilatory and cardioprotective effects that could compound the blood pressure lowering action of ACE inhibitors. While the interaction is not well characterized by large trials, the physiological plausibility warrants monitoring, particularly in patients on multiple antihypertensives.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 323,131 reports mentioning Lisinopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lisinopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Rhodiola interactions → · All Lisinopril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.