Is ACE2 enzyme (oral supplement) Safe with Lisinopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not combine oral ACE2 enzyme supplements with lisinopril; lisinopril inhibits ACE2 activity at significantly lower doses than other ACE inhibitors, making this combination particularly likely to negate the therapeutic benefit of ACE2 supplementation.
Why this interaction occurs
In vitro data demonstrated that lisinopril inhibited rhACE2 activity at much lower concentrations compared to enalapril and benazeprilat, indicating a potent off-target effect on ACE2 that would substantially diminish the effectiveness of any oral ACE2 supplementation strategy.
Evidence
Evidence level: limited.
Data source
PubMed - PMID 39837966
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 323,131 reports mentioning Lisinopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lisinopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All ACE2 enzyme (oral supplement) interactions → · All Lisinopril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.