Is Saccharomyces boulardii Safe with Fluconazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do NOT take Saccharomyces boulardii concurrently with fluconazole or any systemic azole antifungal. These medications will completely inactivate the probiotic. Use an alternative probiotic such as Lactobacillus or Bifidobacterium strains during antifungal therapy.
Why this interaction occurs
Saccharomyces boulardii is a yeast-based probiotic that is directly killed by azole antifungals, including fluconazole, which inhibit ergosterol synthesis in fungal cell membranes. This renders the supplement entirely ineffective and represents a pharmacodynamic incompatibility. This interaction is well-documented and clinically significant.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,684 reports mentioning Fluconazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Fluconazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Saccharomyces boulardii interactions → · All Fluconazole interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.