Is Vitamin D Safe with Fluconazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Standard-dose vitamin D supplementation is generally safe during fluconazole therapy. Avoid high-dose vitamin D (above 4000 IU/day) without medical supervision. Routine monitoring is not required for standard supplementation courses.
Why this interaction occurs
Fluconazole is a potent CYP3A4 and CYP2C9 inhibitor. Vitamin D3 is metabolized partly via CYP3A4. Theoretically, fluconazole could modestly reduce vitamin D catabolism, but this interaction is not considered clinically significant at standard supplementation doses during typical short courses of fluconazole.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,684 reports mentioning Fluconazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Fluconazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Fluconazole interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.