Is Serrapeptase Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take serrapeptase while on warfarin without physician supervision. If use is necessary, increase INR monitoring frequency and watch for symptoms of bleeding including prolonged wound bleeding, nosebleeds, or blood in urine.
Why this interaction occurs
Serrapeptase is a proteolytic enzyme with documented fibrinolytic activity. It can break down fibrin clots and enhance the anticoagulant effect of warfarin through additive antithrombotic mechanisms, increasing the risk of hemorrhagic complications.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Serrapeptase interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.