Is Tongkat Ali Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid Tongkat Ali if you are taking warfarin unless approved by your physician. If concurrent use occurs, monitor INR at least weekly until stable. Discontinue immediately and seek medical attention if unusual bleeding occurs.
Why this interaction occurs
Tongkat Ali (Eurycoma longifolia) contains quassinoids and alkaloids that may inhibit CYP2C9, the primary enzyme responsible for warfarin (S-enantiomer) metabolism. Inhibition of this enzyme can significantly increase warfarin plasma concentrations, raising the risk of serious or life-threatening hemorrhage.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Tongkat Ali interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.