Is EPA (Eicosapentaenoic Acid) Safe with Lisinopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood pressure periodically when using high-dose EPA with ACE inhibitors. This combination may be beneficial but check with your prescriber, especially if you experience dizziness.
Why this interaction occurs
EPA contributes to vasodilation via nitric oxide pathway enhancement and prostaglandin modulation. Combined with ACE inhibitors, there may be a mild additive blood pressure-lowering effect, generally modest in magnitude.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 323,131 reports mentioning Lisinopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lisinopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All EPA (Eicosapentaenoic Acid) interactions → · All Lisinopril interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.