Is Evening Primrose Oil Safe with Aspirin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution when combining Evening Primrose Oil with aspirin, particularly at higher doses. Watch for signs of unusual bruising or prolonged bleeding. Consult your pharmacist or physician before concurrent use.
Why this interaction occurs
Both aspirin and Evening Primrose Oil independently inhibit platelet aggregation through different pathways — aspirin via COX-1 inhibition and EPO via GLA-mediated thromboxane A2 reduction. Combined use produces an additive antiplatelet effect increasing bleeding risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 617,935 reports mentioning Aspirin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Aspirin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Evening Primrose Oil interactions → · All Aspirin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.