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Is EPA (Eicosapentaenoic Acid) Safe with Aspirin?

ℹ️ MODERATE SEVERITY
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Aspirin EPA (Eicosapentaenoic Acid)
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Low-dose aspirin combinations may be acceptable under medical supervision. Avoid high-dose EPA with full-dose aspirin therapy. Report unusual bruising to your provider.

Why this interaction occurs

EPA and aspirin both suppress thromboxane A2-mediated platelet aggregation. Combined use can compound platelet inhibition, prolonging bleeding time.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 617,935 reports mentioning Aspirin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Aspirin + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take EPA (Eicosapentaenoic Acid) with Aspirin?
Low-dose aspirin combinations may be acceptable under medical supervision. Avoid high-dose EPA with full-dose aspirin therapy. Report unusual bruising to your provider.

Related interactions

EPA (Eicosapentaenoic Acid) and Warfarin EPA (Eicosapentaenoic Acid) and Clopidogrel EPA (Eicosapentaenoic Acid) and Lisinopril Ginkgo biloba and Aspirin Bilberry and Aspirin Turmeric and Aspirin Bromelain and Aspirin Evening Primrose Oil and Aspirin

All EPA (Eicosapentaenoic Acid) interactions →  ·  All Aspirin interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.