Is Evening Primrose Oil Safe with Clopidogrel?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Evening Primrose Oil with Clopidogrel unless directed by a physician. Report any unusual bruising, prolonged bleeding from cuts, or blood in urine/stool to your healthcare provider immediately.
Why this interaction occurs
Clopidogrel irreversibly inhibits P2Y12 ADP receptors on platelets. Evening Primrose Oil adds further platelet inhibition through GLA-mediated suppression of thromboxane A2, producing a synergistic antiplatelet effect that significantly elevates hemorrhagic risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 108,615 reports mentioning Clopidogrel. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Clopidogrel + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Evening Primrose Oil interactions → · All Clopidogrel interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.