Is EPA (Eicosapentaenoic Acid) Safe with Clopidogrel?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use with caution. Consult your prescriber or pharmacist before combining. Watch for signs of bleeding such as prolonged bleeding from cuts or blood in stool.
Why this interaction occurs
Both EPA and clopidogrel independently inhibit platelet aggregation through different pathways, creating an additive antiplatelet effect that increases hemorrhagic risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 108,615 reports mentioning Clopidogrel. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Clopidogrel + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All EPA (Eicosapentaenoic Acid) interactions → · All Clopidogrel interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.