Is Ginkgo Biloba Safe with Apixaban?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do NOT take ginkgo biloba with apixaban. This combination should be strictly avoided. If currently using ginkgo, discontinue it and consult your doctor before making any changes to your regimen. Seek emergency care for any signs of serious bleeding.
Why this interaction occurs
Ginkgo biloba contains ginkgolides that potently inhibit platelet-activating factor (PAF) and reduce platelet aggregation. Combined with apixaban's Factor Xa inhibition, this dual mechanism creates a critical additive hemorrhagic risk, with case reports of spontaneous bleeding including intracranial hemorrhage.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 67,478 reports mentioning Apixaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Apixaban + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Ginkgo Biloba interactions → · All Apixaban interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.