Is Fish Oil Safe with Apixaban?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid high-dose fish oil (≥3g/day) while taking apixaban. If using low doses (≤1g/day), monitor for unusual bruising, prolonged bleeding from cuts, or blood in urine/stool. Inform your doctor before combining.
Why this interaction occurs
High-dose omega-3 fatty acids inhibit platelet aggregation via thromboxane A2 suppression and may reduce platelet-activating factor synthesis. Combined with apixaban's Factor Xa inhibition, this creates a synergistic antiplatelet and anticoagulant effect, significantly elevating hemorrhagic risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 67,478 reports mentioning Apixaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Apixaban + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Fish Oil interactions → · All Apixaban interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.