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Is Curcumin Safe with Ibuprofen?

⚠️ HIGH SEVERITY
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Ibuprofen Curcumin
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Curcumin with Ibuprofen — Curcumin blocks the liver enzyme (CYP2C9) that processes Ibuprofen, potentially raising Ibuprofen levels to toxic range. Consult your doctor or pharmacist.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 218,701 reports mentioning Ibuprofen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ibuprofen + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Curcumin with Ibuprofen?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Curcumin with Ibuprofen — Curcumin blocks the liver enzyme (CYP2C9) that processes Ibuprofen, potentially raising Ibuprofen levels to toxic range. Consult your doctor or pharmacist.

Related interactions

Fish Oil and Ibuprofen Willow Bark and Ibuprofen Turmeric and Ibuprofen Bromelain and Ibuprofen Devils Claw and Ibuprofen St. John's Wort and Ibuprofen Milk Thistle and Ibuprofen Ginkgo Biloba and Ibuprofen

All Curcumin interactions →  ·  All Ibuprofen interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.