Is Devils Claw Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your prescriber if you are using Devil's Claw alongside Warfarin. Monitor INR more frequently. Watch for unusual bruising, nosebleeds, or prolonged bleeding from cuts. Do not start or stop Devil's Claw without medical guidance.
Why this interaction occurs
Case reports and pharmacological data suggest Devil's Claw may inhibit CYP2C9, the primary enzyme responsible for Warfarin metabolism, potentially increasing Warfarin plasma levels and bleeding risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Devils Claw interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.