Is EPA (Eicosapentaenoic Acid) Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor INR closely if combining. Inform your prescriber before starting EPA supplements. Do not exceed 3g/day of EPA without medical supervision.
Why this interaction occurs
EPA inhibits platelet aggregation and may have additive anticoagulant effects with warfarin, potentially elevating INR and increasing hemorrhagic risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All EPA (Eicosapentaenoic Acid) interactions → · All Warfarin interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.