Is Fish Oil Safe with Rivaroxaban?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Limit fish oil to dietary sources only. Avoid supplemental doses ≥3g/day. Report any signs of unusual bleeding immediately, including blood in urine, black stools, or prolonged nosebleeds.
Why this interaction occurs
Omega-3 fatty acids at high doses reduce platelet activation and aggregation independently of the coagulation cascade. Rivaroxaban already impairs clot formation by blocking Factor Xa; adding antiplatelet activity from fish oil compounds bleeding risk, particularly gastrointestinal hemorrhage.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 28,402 reports mentioning Rivaroxaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Rivaroxaban + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Fish Oil interactions → · All Rivaroxaban interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.