Is Ginkgo Safe with Rivaroxaban?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid ginkgo biloba entirely while taking rivaroxaban. This combination significantly raises the risk of life-threatening bleeding. Inform your doctor if you have been using ginkgo before starting rivaroxaban therapy.
Why this interaction occurs
Ginkgolides in ginkgo biloba irreversibly inhibit platelet-activating factor receptors, impairing platelet function. This strong antiplatelet effect, combined with rivaroxaban's Factor Xa blockade, dramatically increases the risk of major hemorrhagic events. Multiple case reports document bleeding complications with ginkgo and anticoagulant combinations.
Evidence
Evidence level: strong.
Data source
PubMed: PMID 35517810
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 28,402 reports mentioning Rivaroxaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Rivaroxaban + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Ginkgo interactions → · All Rivaroxaban interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.