Is Magnesium Safe with Citalopram?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider supplementing with 200–400 mg of magnesium glycinate or magnesium citrate daily. Monitor for GI side effects. Check serum magnesium if symptoms of deficiency appear (muscle cramps, anxiety, fatigue).
Why this interaction occurs
SSRIs including citalopram may contribute to magnesium depletion through increased urinary excretion and altered intracellular transport. Magnesium plays a key role in NMDA receptor modulation and serotonin synthesis. Deficiency can worsen anxiety, depression, and muscle tension, potentially undermining treatment outcomes.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 113,877 reports mentioning Citalopram. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Citalopram + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Citalopram interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.